Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

Extracellular histones play a dual role—antimicrobial and cytotoxic—in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties. Broth microdilution assays indicated that histone H3 exhibi...

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Bibliographic Details
Main Authors: Yuri Tanaka, Nanako Yamanaka, Izumi Koyano, Itaru Hasunuma, Tetsuya Kobayashi, Sakae Kikuyama, Shawichi Iwamuro
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Antibiotics
Subjects:
histone H3
antimicrobial activity
cytotoxicity
cell membrane destruction
ELEBA
Online Access:https://www.mdpi.com/2079-6382/11/9/1240

Internet

https://www.mdpi.com/2079-6382/11/9/1240

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