Double somatic mutations in CTNNB1 and GNA11 in an aldosterone-producing adenoma

Double somatic mutations in CTNNB1 and GNA11 in an aldosterone-producing adenoma

Double somatic mutations in CTNNB1 and GNA11/Q have recently been identified in a small subset of aldosterone-producing adenomas (APAs). As a possible pathogenesis of APA due to these mutations, an association with pregnancy, menopause, or puberty has been proposed. However, because of its rarity, c...

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Bibliographic Details
Main Authors: Kazutaka Nanba, Amy R. Blinder, Aaron M. Udager, Yuusuke Hirokawa, Takayoshi Miura, Hiroshi Okuno, Koki Moriyoshi, Yuto Yamazaki, Hironobu Sasano, Akihiro Yasoda, Noriko Satoh-Asahara, William E. Rainey, Tetsuya Tagami
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Endocrinology
Subjects:
primary aldosteronism
aldosterone-producing adenoma
CYP11B2
somatic mutation
CTNNB1
GNA11
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1286297/full

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https://www.frontiersin.org/articles/10.3389/fendo.2024.1286297/full

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