APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress

APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress

Abstract Background Apurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER) pathway, but whether and how it is involved in the formation and/or repair of DSBs remains mostly unknown. Methods Immunoblotting, fluorescent imm...

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Bibliographic Details
Main Authors: Qin Zhang, Lujie Yang, Han Gao, Xunjie Kuang, He Xiao, Chen Yang, Yi Cheng, Lei Zhang, Xin Guo, Yong Zhong, Mengxia Li
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
DNA-PKcs
DNA damage response
Radio-resistance
ATM
Online Access:https://doi.org/10.1186/s12967-023-04022-9

Internet

https://doi.org/10.1186/s12967-023-04022-9

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