DRAK2 Participates in a Negative Feedback Loop to Control TGF-β/Smads Signaling by Binding to Type I TGF-β Receptor

DRAK2 Participates in a Negative Feedback Loop to Control TGF-β/Smads Signaling by Binding to Type I TGF-β Receptor

TGF-β1 is a multifunctional cytokine that mediates diverse biological processes. However, the mechanisms by which the intracellular signals of TGF-β1 are terminated are not well understood. Here, we demonstrate that DRAK2 serves as a TGF-β1-inducible antagonist of TGF-β signaling. TGF-β1 stimulation...

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Bibliographic Details
Main Authors: Kyung-Min Yang, Wonjoo Kim, Eunjin Bae, Jungsoo Gim, Brian M. Weist, Yunshin Jung, Ja-Shil Hyun, Jennifer B. Hernandez, Sun-Hee Leem, Taesung Park, Joon Jeong, Craig M. Walsh, Seong-Jin Kim
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003324

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http://www.sciencedirect.com/science/article/pii/S2211124712003324

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