Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses

Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses

Rho GTPase signaling promotes proliferation, invasion, and metastasis in a broad spectrum of cancers. Rho GTPase activity is regulated by the deleted in liver cancer (DLC) family of bona fide tumor suppressors which directly inactivate Rho GTPases by stimulating GTP hydrolysis. In addition to a RhoG...

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Bibliographic Details
Main Authors: Ashton S. Holub, Renee A. Bouley, Ruben C. Petreaca, Aman Y. Husbands
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
evolution
structure-function analysis
ligand-binding domain
tumor suppressor
computational genomics
COSMIC
Online Access:https://www.mdpi.com/1422-0067/21/21/8175

Internet

https://www.mdpi.com/1422-0067/21/21/8175

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