A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand

A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand

Changes in the expression of α7 nicotinic acetylcholine receptors (α7 nAChRs) in the human brain are widely assumed to be associated with neurological and neurooncological processes. Investigation of these receptors in vivo depends on the availability of imaging agents such as radioactively labelled...

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Bibliographic Details
Main Authors: Rodrigo Teodoro, Matthias Scheunemann, Winnie Deuther-Conrad, Barbara Wenzel, Francesca Maria Fasoli, Cecilia Gotti, Mathias Kranz, Cornelius K. Donat, Marianne Patt, Ansel Hillmer, Ming-Qiang Zheng, Dan Peters, Jörg Steinbach, Osama Sabri, Yiyun Huang, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
α7 nAChR
pharmacophore
positron emission tomography
neuroimaging
fluorine-18
Online Access:http://www.mdpi.com/1420-3049/20/10/18387

Internet

http://www.mdpi.com/1420-3049/20/10/18387

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