Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

Identifying determinants of broadly neutralizing antibodies against hepatitis C virus (HCV) may guide HCV vaccine design. Here, the authors discover new anti-HCV antibodies using computational screening and analyze the amino acid composition and sequence-structure relationships in this antibody fami...

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Bibliographic Details
Main Authors: Nina G. Bozhanova, Andrew I. Flyak, Benjamin P. Brown, Stormy E. Ruiz, Jordan Salas, Semi Rho, Robin G. Bombardi, Luke Myers, Cinque Soto, Justin R. Bailey, James E. Crowe, Pamela J. Bjorkman, Jens Meiler
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30865-9

Internet

https://doi.org/10.1038/s41467-022-30865-9

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