Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival

Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival

Protein phosphatase 2A (PP2A) is a major cellular phosphatase with many protein substrates. As expected for a signaling molecule with many targets, inhibition of PP2A disrupts fundamental aspects of cellular physiology including cell division and survival. In post-mitotic neurons, the microtubule as...

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Bibliographic Details
Main Authors: Margaret Hayne, Aaron DiAntonio
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Neurobiology of Disease
Subjects:
PP2A
DLK
Tau
Neurodegeneration
Synapse development
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121003351

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http://www.sciencedirect.com/science/article/pii/S0969996121003351

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