Structural New Data for Mitochondrial Peroxiredoxin From Trypanosoma cruzi Show High Similarity With Human Peroxiredoxin 3: Repositioning Thiostrepton as Antichagasic Drug

Structural New Data for Mitochondrial Peroxiredoxin From Trypanosoma cruzi Show High Similarity With Human Peroxiredoxin 3: Repositioning Thiostrepton as Antichagasic Drug

Trypanosoma cruzi, the causal agent of Chagas disease, has peroxiredoxins (PRXs) expressed in all stages of the parasite and whose function is to detoxify oxidizing agents, such as reactive oxygen species (ROS). These proteins are central for the survival and replication of the parasite and have bee...

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Bibliographic Details
Main Authors: Lucio Rivera-Santiago, Ignacio Martínez, Ruben Arroyo-Olarte, Paulina Díaz-Garrido, Roberto I. Cuevas-Hernandez, Bertha Espinoza
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
mitochondrial peroxiredoxin
bioinformatic analysis
repositioning Thiostrepton
trypanocidal activity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.907043/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.907043/full

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