Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype

Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype

Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, emerging evidence suggests a role for viral pathogens. Toll-l...

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Bibliographic Details
Main Authors: Flavia Trionfetti, Claudia Montaldo, Ivan Caiello, Giulio Bontempi, Michela Terri, Marta Tiberi, Vanessa Marchant, Alessandro Domenici, Paolo Menè, Marco Cordani, Clemens Zwergel, Giusi Prencipe, Marta Ruiz-Ortega, Sergio Valente, Antonello Mai, Marco Tripodi, Raffaele Strippoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
mesothelial cells
HDAC
viral infections
MMT
interferon response
inflammatory cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1308362/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1308362/full

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