Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)

Relaxin family peptide receptor 4 (RXFP4) regulates pleiotropic biological processes. Here, authors report cryo-EM structures revealing the ligand-binding modes and key determinants of peptidomimetic agonism and subtype selectivity

Bibliographic Details
Main Authors: Yan Chen, Qingtong Zhou, Jiang Wang, Youwei Xu, Yun Wang, Jiahui Yan, Yibing Wang, Qi Zhu, Fenghui Zhao, Chenghao Li, Chuan-Wei Chen, Xiaoqing Cai, Ross A .D. Bathgate, Chun Shen, H. Eric Xu, Dehua Yang, Hong Liu, Ming-Wei Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36182-z

Internet

https://doi.org/10.1038/s41467-023-36182-z

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