Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells

Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells

The trabecular meshwork (TM) route is the principal outflow egress of the aqueous humor. Actin cytoskeletal remodeling in the TM and extracellular matrix (ECM) deposition increase TM stiffness, outflow resistance, and elevate intraocular pressure (IOP). These alterations are strongly linked to trans...

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Bibliographic Details
Main Authors: Minh Ngoc Tran, Timea Medveczki, Balazs Besztercei, Gyorgy Torok, Attila J. Szabo, Xavier Gasull, Illes Kovacs, Andrea Fekete, Judit Hodrea
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Life
Subjects:
Sigma-1 receptor
fluvoxamine
TGFβ2
trabecular meshwork
extracellular matrix
cytoskeletal remodeling
Online Access:https://www.mdpi.com/2075-1729/13/7/1581

Internet

https://www.mdpi.com/2075-1729/13/7/1581

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