REV-ERB is essential in cardiac fibroblasts homeostasis

REV-ERB is essential in cardiac fibroblasts homeostasis

REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac fibroblasts using genetic deletion of REV-ERBα a...

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Bibliographic Details
Main Authors: Xiaokang Luo, Shiyang Song, Lei Qi, Chih-Liang Tien, Hui Li, Weiyi Xu, Theodore Lemuel Mathuram, Thomas Burris, Yuanbiao Zhao, Zheng Sun, Lilei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
REV-ERB
fibroblast activation
SR9009
cardiac fibroblasts
TGFβ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.899628/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.899628/full

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