Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer.

Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer.

Ovarian cancer is the most lethal gynecological disease affecting women in the US. The Cancer Genome Atlas Network identified p53 mutations in 96% of high-grade serous ovarian carcinomas, demonstrating its critical role. Additionally, the Transforming Growth Factor Beta (TGFβ) pathway is dysfunction...

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Bibliographic Details
Main Authors: Eoghainín Ó hAinmhire, Suzanne M Quartuccio, Whay Cheng, Roshan A Ahmed, Shelby M King, Joanna E Burdette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586866/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586866/pdf/?tool=EBI

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