Inhibitory effect of AK-7 mediates by apoptosis, increases DNA fragmentation and caspase-3 activity in human glioblastoma multiforme cells

Inhibitory effect of AK-7 mediates by apoptosis, increases DNA fragmentation and caspase-3 activity in human glioblastoma multiforme cells

Sirtuins (SIRTs) which are nicotinamide adenine dinucleotide (NAD+) dependent class III histondeacetylases have a controversial role in cancer. In this study, the effect of pharmacological inhibition of AK-7, a SIRT2 inhibitor, was investigated in U87 glioblastoma multiforme cells. The cytotoxic ef...

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Bibliographic Details
Main Authors: Ebru Güçlü, İlknur Çınar Ayan, Hasibe Vural
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2022-06-01
Series:Bangladesh Journal of Pharmacology
Subjects:
AK-7
Apoptosis
Glioblastoma multiforme
Sirtuin 2
SIRT2 inhibitor
qRT-PCR
Online Access:https://www.banglajol.info/index.php/BJP/article/view/59809

Internet

https://www.banglajol.info/index.php/BJP/article/view/59809

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