Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers, are associated with nucleotide metabolic dys...

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Bibliographic Details
Main Authors: Dashnamoorthy Ravi, Afshin Beheshti, Nasséra Abermil, Frederick Lansigan, William Kinlaw, Nirupa R. Matthan, Maisarah Mokhtar, Frank C. Passero, Patrick Puliti, Kevin A. David, Gregory G. Dolnikowski, Xiaoyang Su, Ying Chen, Mahboubi Bijan, Rohan R. Varshney, Baek Kim, Sandeep S. Dave, Michael C. Rudolph, Andrew M. Evens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
non-Hodgkin lymphoma
FASN
metabolomics
nucleotides
pentose phosphate pathway
lipid metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.725137/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.725137/full

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