Discovery and Characterization of Polymyxin-Resistance Genes pmrE and pmrF from Sediment and Seawater Microbiome

Discovery and Characterization of Polymyxin-Resistance Genes pmrE and pmrF from Sediment and Seawater Microbiome

ABSTRACT Polymyxins are the last-line antibiotics used to treat Gram-negative pathogens. Thus, the discovery and biochemical characterization of the resistance genes against polymyxins are urgently needed for diagnosis, treatment, and novel antibiotic design. Herein, we report novel polymyxin-resist...

Full description

Bibliographic Details
Main Authors: Hwanjin Joo, Hyunuk Eom, Youna Cho, Mina Rho, Woon Ju Song
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
polymyxin
antibiotic resistance
metagenome
UDP-glucose dehydrogenase
undecaprenyl-phosphate 4-deoxy-4-formamido-l-arabinose transferase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02736-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02736-22

Similar Items