Statistical methods for exploring spontaneous adverse event reporting databases for drug-host factor interactions

Statistical methods for exploring spontaneous adverse event reporting databases for drug-host factor interactions

Abstract Background Drug toxicity does not affect patients equally; the toxicity may only exert in patients who possess certain attributes of susceptibility to specific drug properties (i.e., drug-host interaction). This concept is crucial for personalized drug safety but remains under-studied, prim...

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Bibliographic Details
Main Authors: Zhiyuan Lu, Ayako Suzuki, Dong Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Medical Research Methodology
Subjects:
Drug-host factor interactions
Likelihood ratio tests
FAERS
Postmarket surveillance
Spontaneous reporting adverse event databases
Online Access:https://doi.org/10.1186/s12874-023-01885-w

Internet

https://doi.org/10.1186/s12874-023-01885-w

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