Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway

Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway

Introduction: Angiogenesis is an essential feature of liver cancer. Tumor hypoxia results from abnormal vessel architecture. Numerous studies have sufficiently demonstrated that Tanshinone IIA (Tan IIA) can increase blood flow and enhance microcirculation. The objectives of this study are to: 1 asse...

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Bibliographic Details
Main Authors: Chengdong Qin, Siyuan Liu, Shiqi Zhou, Xianghou Xia, Jiejie Hu, Yang Yu, Dening Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
tanshinone IIA
hepatocellular carcinoma
angiogenesis
sorafenib
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1189532/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1189532/full

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