Novel Synthesized <i>N</i>-Ethyl-Piperazinyl-Amides of C2-Substituted Oleanonic and Ursonic Acids Exhibit Cytotoxic Effects through Apoptotic Cell Death Regulation

Novel Synthesized <i>N</i>-Ethyl-Piperazinyl-Amides of C2-Substituted Oleanonic and Ursonic Acids Exhibit Cytotoxic Effects through Apoptotic Cell Death Regulation

A series of novel hybrid chalcone N-ethyl-piperazinyl amide derivatives of oleanonic and ursonic acids were synthesized, and their cytotoxic potential was evaluated in vitro against the NCI-60 cancer cell line panel. Compounds <b>4</b> and <b>6</b> exhibited the highest overa...

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Bibliographic Details
Main Authors: Oxana Kazakova, Alexandra Mioc, Irina Smirnova, Irina Baikova, Adrian Voicu, Lavinia Vlaia, Ioana Macașoi, Marius Mioc, George Drăghici, Ştefana Avram, Cristina Dehelean, Codruța Şoica
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
oleanonic acid
ursonic acid
arylidene
piperazine
anticancer activity
NCI-60
Online Access:https://www.mdpi.com/1422-0067/22/20/10967

Internet

https://www.mdpi.com/1422-0067/22/20/10967

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