PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2

PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2

Background: Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta (PGC-1β) and Estrogen-Related Receptor Alpha (ERRα) are over-expressed in colorectal cancer and promote tumor survival. Methods: In this study, we use immunoprecipitation of epitope tagg...

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Bibliographic Details
Main Authors: Danielle E. Frodyma, Thomas C. Troia, Chaitra Rao, Robert A. Svoboda, Jordan A. Berg, Dhananjay D. Shinde, Vinai C. Thomas, Robert E. Lewis, Kurt W. Fisher
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
PGC-1β
colorectal cancer
ERRα
PCK2
metabolism
K-Ras
Online Access:https://www.mdpi.com/2072-6694/14/19/4879

Internet

https://www.mdpi.com/2072-6694/14/19/4879

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