A Mixed-Surface Polyamidoamine Dendrimer for In Vitro and In Vivo Delivery of Large Plasmids

A Mixed-Surface Polyamidoamine Dendrimer for In Vitro and In Vivo Delivery of Large Plasmids

Drug delivery to the brain is highly hindered by the presence of the blood–brain barrier (BBB), which prevents the entry of many potential drugs/biomolecules into the brain. One of the current strategies to achieve gene therapy for neurodegenerative diseases involves direct injection of a viral vect...

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Bibliographic Details
Main Authors: Bhairavi Srinageshwar, Maria Florendo, Brittany Clark, Kayla Johnson, Nikolas Munro, Sarah Peruzzaro, Aaron Antcliff, Melissa Andrews, Alexander Figacz, Douglas Swanson, Gary L. Dunbar, Ajit Sharma, Julien Rossignol
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
mixed-surface polyamidoamine dendrimers
gene delivery
glial cells
large plasmid
Sox2
Online Access:https://www.mdpi.com/1999-4923/12/7/619

Internet

https://www.mdpi.com/1999-4923/12/7/619

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