Recent advances and limitations of mTOR inhibitors in the treatment of cancer

Recent advances and limitations of mTOR inhibitors in the treatment of cancer

Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transf...

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Bibliographic Details
Main Authors: Eunus S. Ali, Kangkana Mitra, Shamima Akter, Sarker Ramproshad, Banani Mondal, Ishaq N. Khan, Muhammad Torequl Islam, Javad Sharifi-Rad, Daniela Calina, William C. Cho
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cancer Cell International
Subjects:
Cancer
Rapamycin
mTOR pathway
mTORC1
mTORC2
mTOR inhibitors
Online Access:https://doi.org/10.1186/s12935-022-02706-8

Internet

https://doi.org/10.1186/s12935-022-02706-8

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