Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

Renal medullary carcinoma (RMC) is a lethal malignancy affecting individuals with sickle hemoglobinopathies. Currently, no modifiable risk factors are known. We aimed to determine whether high-intensity exercise is a risk factor for RMC in individuals with sickle cell trait (SCT). We used multiple a...

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Bibliographic Details
Main Authors: Daniel D. Shapiro, Melinda Soeung, Luigi Perelli, Eleonora Dondossola, Devaki Shilpa Surasi, Durga N. Tripathi, Jean-Philippe Bertocchio, Federica Carbone, Michael W. Starbuck, Michael L. Van Alstine, Priya Rao, Matthew H. G. Katz, Nathan H. Parker, Amishi Y. Shah, Alessandro Carugo, Timothy P. Heffernan, Keri L. Schadler, Christopher Logothetis, Cheryl L. Walker, Christopher G. Wood, Jose A. Karam, Giulio F. Draetta, Nizar M. Tannir, Giannicola Genovese, Pavlos Msaouel
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
renal medullary carcinoma
exercise
hypoxia
risk factor
Online Access:https://www.mdpi.com/2072-6694/13/23/6022

Internet

https://www.mdpi.com/2072-6694/13/23/6022

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