Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release

Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release

The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of human multiple sclerosis (MS) and mouse experimental autoimmune encephalomyelitis (EAE). Glycyrrhizin (GL), a glycoconjugated triterpene extracted from licorice root, has the ability to inhibit t...

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Bibliographic Details
Main Authors: Yan Sun, Huoying Chen, Jiapei Dai, Zhongjun Wan, Ping Xiong, Yong Xu, Zhengrong Han, Weitai Chai, Feili Gong, Fang Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
high-mobility group box 1
experimental autoimmune encephalomyelitis
multiple sclerosis
glycyrrhizin
neurons
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01518/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01518/full

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