A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

BackgroundChronic obstructive pulmonary disease (COPD) is a major cause of chronic mortality. The objective of this study was to investigate the therapeutic potential of a novel potent histone deacetylase (HDAC) inhibitor MPT0E028 on emphysema.Materials and MethodsA mouse model of porcine pancreatic...

Full description

Bibliographic Details
Main Authors: Lu-Yang Yeh, Yu-Ting Fang, Hong-Sheng Lee, Chia-Hao Liu, You-Yin Chen, Yu-Chun Lo, Vincent Laiman, Jing-Ping Liou, Kian Fan Chung, Hsiao-Chi Chuang, Chien-Huang Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Medicine
Subjects:
alveolar
apoptosis
COPD
HDAC
inflammation
TAZ
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.794025/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.794025/full

Similar Items