Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

Utrophin is a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin. Here the authors report that inactivation of the protein deacetylase SIRT6, involved in the deacetylation of the epigenetic mark H3K56ac in muscle cells, increases expression of utrophin and ameliorates dys...

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Bibliographic Details
Main Authors: Angelina M. Georgieva, Xinyue Guo, Marek Bartkuhn, Stefan Günther, Carsten Künne, Christian Smolka, Ann Atzberger, Ulrich Gärtner, Kamel Mamchaoui, Eva Bober, Yonggang Zhou, Xuejun Yuan, Thomas Braun
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31798-z

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https://doi.org/10.1038/s41467-022-31798-z

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