Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function. The CholS/Chol ratio decreases during SC maturation but remains high in pathological conditions, such as X-linked ichthyosis, chara...

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Bibliographic Details
Main Authors: Ferdinand Fandrei, Oskar Engberg, Lukáš Opálka, Pavla Jančálková, Petra Pullmannová, Miloš Steinhart, Andrej Kováčik, Kateřina Vávrová, Daniel Huster
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Lipid Research
Subjects:
lipid packing
order parameter
sterols
nanostructure
permeability
ceramides
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000104

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http://www.sciencedirect.com/science/article/pii/S0022227522000104

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