Long-term cyclosporine A treatment promotes anxiety-like behavior: Possible relation with glutamate signaling in rat hippocampus

Long-term cyclosporine A treatment promotes anxiety-like behavior: Possible relation with glutamate signaling in rat hippocampus

Background: Chronic immunosuppressive treatment with cyclosporine A (CsA) leads to multiple side effects, including some that occur in the central nervous system (CNS). This study aims to investigate the impact of long-term CsA treatment on anxiety behavior and verify the alterations related to glut...

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Bibliographic Details
Main Authors: Marina Minto Cararo-Lopes, Débora Guerini Souza, Marcelo Ganzella, Gisele Hansel, Vanessa Kazlauckas, Paloma Segura De Mello, Larissa De Sá Lima, Elisa Mitiko Kawamoto, Luis Valmor Portela, Diogo Onofre Souza, Cristoforo Scavone, Ana Elisa Böhmer
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Affective Disorders Reports
Subjects:
Cyclosporine
Anxiety
Glutamate
N-methyl-D-aspartate receptors
CREB
Nitric oxide synthase
Online Access:http://www.sciencedirect.com/science/article/pii/S2666915322000865

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http://www.sciencedirect.com/science/article/pii/S2666915322000865

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