Robust analysis of allele-specific copy number alterations from scRNA-seq data with XClone

Abstract Somatic copy number alterations (CNAs) are major mutations that contribute to the development and progression of various cancers. Despite a few computational methods proposed to detect CNAs from single-cell transcriptomic data, the technical sparsity of such data makes it challenging to ide...

Full description

Bibliographic Details
Main Authors: Rongting Huang, Xianjie Huang, Yin Tong, Helen Y. N. Yan, Suet Yi Leung, Oliver Stegle, Yuanhua Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51026-0