Robust analysis of allele-specific copy number alterations from scRNA-seq data with XClone
Abstract Somatic copy number alterations (CNAs) are major mutations that contribute to the development and progression of various cancers. Despite a few computational methods proposed to detect CNAs from single-cell transcriptomic data, the technical sparsity of such data makes it challenging to ide...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-51026-0 |