Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]

Lilly PCSK9 antibody LY3015014 (LY) is a monoclonal antibody (mAb) that neutralizes proprotein convertase subtilisin-kexin type 9 (PCSK9). LY decreases LDL cholesterol in monkeys and, unlike other PCSK9 mAbs, does not cause an accumulation of intact PCSK9 in serum. Comparing the epitope of LY with o...

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Bibliographic Details
Main Authors: Krista M. Schroeder, Thomas P. Beyer, Ryan J. Hansen, Bomie Han, Richard T. Pickard, Victor J. Wroblewski, Mark C. Kowala, Patrick I. Eacho
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Lipid Research
Subjects:
proprotein convertase subtilisin-kexin type 9
pharmacology
pharmacokinetics
low density lipoprotein/metabolism
drug therapy
dyslipidemias
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752035481X

Internet

http://www.sciencedirect.com/science/article/pii/S002222752035481X

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