Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression

Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression

Colorectal cancer (CRC) remains one of the most common malignancies worldwide and its mechanism is unclear. Polymeric immunoglobulin receptor (PIGR) which plays an important role in mucosal immunity is widely expressed in the mucosal epithelium and is dysregulated in different tumors. However, the r...

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Bibliographic Details
Main Authors: Ding Zhang, Hao Huang, Ting Zheng, Lei Zhang, Binbin Cui, Yanlong Liu, Shiheng Tan, Liyuan Zhao, Tian Tian, Lijing Gao, Qingzhen Fu, Zesong Cheng, Yashuang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
polymeric immunoglobulin receptor
prognostic marker
AKT-FOXO3/4 axis
methylation-driven gene
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.924988/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.924988/full

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