Molecular Recognition of FDA-Approved Small Molecule Protein Kinase Drugs in Protein Kinases

Molecular Recognition of FDA-Approved Small Molecule Protein Kinase Drugs in Protein Kinases

Protein kinases are key enzymes that catalyze the covalent phosphorylation of substrates via the transfer of the γ-phosphate of ATP, playing a crucial role in cellular proliferation, differentiation, and various cell regulatory processes. Due to their pivotal cellular role, the aberrant function of...

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Bibliographic Details
Main Authors: Yan Zhu, Xiche Hu
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
FDA-approved drugs
molecular recognition
quantum chemical calculations
π-π stacking interactions
CH-π interactions
rational drug design
Online Access:https://www.mdpi.com/1420-3049/27/20/7124

Internet

https://www.mdpi.com/1420-3049/27/20/7124

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