Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease

Abstract Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking. We describe a translational drug discovery platform based on organotypic culture of murine cortical brain slices that recapitulate dise...

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Bibliographic Details
Main Authors: Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate, Jonathan M. Levenson
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:https://doi.org/10.1186/s12974-024-03029-3