Is the Secret of VDAC Isoforms in Their Gene Regulation? Characterization of Human <i>VDAC</i> Genes Expression Profile, Promoter Activity, and Transcriptional Regulators

Is the Secret of VDAC Isoforms in Their Gene Regulation? Characterization of Human <i>VDAC</i> Genes Expression Profile, Promoter Activity, and Transcriptional Regulators

VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs’ presence. In higher eukaryotes, three isoforms are raised during the evolution: they have the same exon–intron organization, and the protein...

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Bibliographic Details
Main Authors: Federica Zinghirino, Xena Giada Pappalardo, Angela Messina, Francesca Guarino, Vito De Pinto
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
VDAC isoforms
gene structure
expression profile
core promoter
transcription factor binding sites
mitochondrial function
Online Access:https://www.mdpi.com/1422-0067/21/19/7388

Internet

https://www.mdpi.com/1422-0067/21/19/7388

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