CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects, and contribution to tumor de...

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Bibliographic Details
Main Authors: Yihui Chen, Michela Capello, Mayrim V. Rios Perez, Jody V. Vykoukal, David Roife, Ya'an Kang, Laura R. Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L. Baluya, Jennifer B. Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J. Chiao, Matthew H.G. Katz, Jason B. Fleming, Samir M. Hanash, Johannes F. Fahrmann
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Molecular Metabolism
Subjects:
PDAC
HNF4α
CES2
Classical/progenitor subtype
Phospholipid catabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821002842

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http://www.sciencedirect.com/science/article/pii/S2212877821002842

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