Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages

Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages

Activated pancreatic stellate cells (aPSCs) and M2 macrophages modulate tumor progression and therapeutic efficacy in pancreatic ductal adenocarcinoma (PDAC) via epithelial-mesenchymal transition (EMT). Here, our aim was to analyze the anti-invasion effects of anti-cancer agents where EMT-inducing c...

Full description

Bibliographic Details
Main Authors: So-Dam Jang, Jeeyeun Song, Hyun-Ah Kim, Chang-Nim Im, Iftikhar Ali Khawar, Jong Kook Park, Hyo-Jeong Kuh
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
pancreatic cancer
tumor microenvironment
tumor spheroid
3D culture
anti-cancer drug
pancreatic stellate cell
Online Access:https://www.mdpi.com/2072-6694/13/23/5955

Internet

https://www.mdpi.com/2072-6694/13/23/5955

Similar Items