Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential

The balance between safety and efficacy of T cell therapies remains challenging and T cell mediated toxicities have occurred. The stringent selection of tumor-specific targets and careful selection of tumor-specific T cells using T cell toxicity screenings are essential. In vitro screening options a...

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Bibliographic Details
Main Authors: Rosa A. van Amerongen, Laura T. Morton, Umesh G. Chaudhari, Dennis F.G. Remst, Renate S. Hagedoorn, Cathelijne W. van den Berg, Christian Freund, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
TCR gene transfer
adoptive T cell therapy
human iPSCs
preclinical screening
toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000074

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http://www.sciencedirect.com/science/article/pii/S2329050123000074

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