Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin

Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin

Colorectal cancer (CRC) forms one of the highest ranked cancer types in the world with its increasing incidence and mortality rates despite the advancement in cancer therapeutics. About 50% of human CRCs are reported to have defective p53 expression resultant of TP53 gene mutation often contributing...

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Bibliographic Details
Main Authors: Lubna Therachiyil, Javeria Haroon, Fairooz Sahir, Kodappully S. Siveen, Shahab Uddin, Michal Kulinski, Joerg Buddenkotte, Martin Steinhoff, Roopesh Krishnankutty
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
colon cancer
HCT 116
HT 29
p53
oxaliplatin
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01744/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01744/full

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