In vivo cortical glutathione response to oral fumarate therapy in relapsing-remitting multiple sclerosis: A single-arm open-label phase IV trial using 7-Tesla 1H MRS

In vivo cortical glutathione response to oral fumarate therapy in relapsing-remitting multiple sclerosis: A single-arm open-label phase IV trial using 7-Tesla 1H MRS

Background: This is an open-label, single-arm, single-center pilot study using 7-Tesla in vivo proton magnetic resonance spectroscopy (1H MRS) to measure brain cortical glutathione concentration at baseline before and during the use of oral fumarates as a disease-modifying therapy for multiple scler...

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Bibliographic Details
Main Authors: Christoph Juchem, Kelley M. Swanberg, Hetty Prinsen, Daniel Pelletier
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:NeuroImage: Clinical
Subjects:
Multiple sclerosis
Fumarate
Glutathione
Prefrontal cortex
Magnetic resonance spectroscopy
7 Tesla
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158223001869

Internet

http://www.sciencedirect.com/science/article/pii/S2213158223001869

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