Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice

Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice

Objective: Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that beta cell dysfunction partakes in this process. We previously reported that genetic deletion and pharmacological antagonism of the c...

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Bibliographic Details
Main Authors: Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F. O’Connell, Isabel González-Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M. Egan, Máire E. Doyle
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Molecular Metabolism
Subjects:
Beta cell apoptosis
Beta cell proliferation
Cannabinoid 1 receptor
Insulitis
Islet of Langerhans
Type 1 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000371

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http://www.sciencedirect.com/science/article/pii/S2212877824000371

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