Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans.

Treating obesity has proven to be an intractable challenge, in part, due to the difficulty of maintaining reduced weight. In our previous studies of in-patient obese subjects, we have shown that leptin repletion following a 10% or greater weight loss reduces many of the metabolic (decreased energy e...

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Bibliographic Details
Main Authors: William Hinkle, Michael Cordell, Rudy Leibel, Michael Rosenbaum, Joy Hirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555620/?tool=EBI