Acyl-protein thioesterase1 alleviates senile osteoporosis by promoting osteoblast differentiation via depalmitoylation of BMPR1a

Acyl-protein thioesterase1 alleviates senile osteoporosis by promoting osteoblast differentiation via depalmitoylation of BMPR1a

Objective: Senile osteoporosis (SOP) is an aging-related disease. The depalmitoylating enzyme Acyl-protein thiesterase1 (APT1) is involved in disease regulation. This study explored the mechanism of APT1 in SOP. Methods: Eight-week-old SAMP6 mice were selected as SOP models and SAMR1 mice were contr...

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Bibliographic Details
Main Authors: Changjiao Ji, Qiaoyan Dong, Huihui Liu, Xiaodeng Yang, Yingguang Han, Bingrui Zhu, Huaixin Xing
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Regenerative Therapy
Subjects:
Senile osteoporosis
APT1
BMPR1a
BMP/Smad
Osteoblast differentiation
Palmitoylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320423000421

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http://www.sciencedirect.com/science/article/pii/S2352320423000421

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