An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat

An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat

Central nervous system (CNS) neurons fail to regrow injured axons, often resulting in permanently lost neurologic function. Tacrolimus is an FDA-approved immunosuppressive drug with known neuroprotective and neuroregenerative properties in the CNS. However, tacrolimus is typically administered syste...

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Bibliographic Details
Main Authors: Yolandi van der Merwe, Anne E. Faust, Ian Conner, Xinzhu Gu, Firuz Feturi, Wenchen Zhao, Bianca Leonard, Souvik Roy, Vijay S. Gorantla, Raman Venkataramanan, Kia M. Washington, William R. Wagner, Michael B. Steketee
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:EBioMedicine
Subjects:
Tacrolimus
FK506
Retinal ganglion cell
CNS
Axon regeneration
Optic nerve
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304607

Internet

http://www.sciencedirect.com/science/article/pii/S2352396417304607

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