Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex

Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex

ABSTRACT The influenza A virus (IAV)-encoded matrix protein 1 (M1) acts as a master regulator of virus replication and fulfills multiple structural and regulatory functions in different cell compartments. Therefore, the spatiotemporal regulation of M1 is achieved by different mechanisms, including i...

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Bibliographic Details
Main Authors: Lu Liu, Axel Weber, Uwe Linne, Mahmoud Shehata, Stephan Pleschka, Michael Kracht, M. Lienhard Schmitz
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
influenza A virus
kinase
signaling
phosphorylation
STRIPAK
budding
Online Access:https://journals.asm.org/doi/10.1128/mbio.03231-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03231-22

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