KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43

KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43

Abstract Background Ossification of ligamentum flavum (OLF) is a prevalent degenerative spinal disease, typically causing severe neurological dysfunction. Kruppel-like factor 5 (KLF5) plays an essential role in the regulation of skeletal development. However, the mechanism KLF5 plays in OLF remains...

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Bibliographic Details
Main Authors: Hubing Guo, Lingxia Yang, Jin Liu, Liqi Chen, Yufeng Huang, Jinsong Li
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
KLF5
Ligamentum flavum
Ossification
CX43
Online Access:https://doi.org/10.1186/s13018-024-04702-2

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