Global Proteotoxicity Caused by Human β<sub>2</sub> Microglobulin Variants Impairs the Unfolded Protein Response in <i>C. elegans</i>
Aggregation of β<sub>2</sub> microglobulin (β<sub>2</sub>m) into amyloid fibrils is associated with systemic amyloidosis, caused by the deposition of amyloid fibrils containing the wild-type protein and its truncated variant, ΔN6 β<sub>2</sub>m, in haemo-dialysed...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-10-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/19/10752 |