Global Proteotoxicity Caused by Human β<sub>2</sub> Microglobulin Variants Impairs the Unfolded Protein Response in <i>C. elegans</i>

Global Proteotoxicity Caused by Human β<sub>2</sub> Microglobulin Variants Impairs the Unfolded Protein Response in <i>C. elegans</i>

Aggregation of β<sub>2</sub> microglobulin (β<sub>2</sub>m) into amyloid fibrils is associated with systemic amyloidosis, caused by the deposition of amyloid fibrils containing the wild-type protein and its truncated variant, ΔN6 β<sub>2</sub>m, in haemo-dialysed...

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Bibliographic Details
Main Authors:	Sarah C. Good, Katherine M. Dewison, Sheena E. Radford, Patricija van Oosten-Hawle
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Series:	International Journal of Molecular Sciences
Subjects:	β<sub>2</sub> microglobulin systemic amyloidosis protein misfolding <i>C. elegans</i> extracellular ER stress
Online Access:	https://www.mdpi.com/1422-0067/22/19/10752

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