Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy

Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy

Doxorubicin (DOX) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe risk of cardiotoxicity. One of the hallmarks of doxorubicin-induced cardiotoxicity (DICT) is the cascade of mitophagy deficiency-mitochondrial oxidative injury-apoptosis, wh...

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Bibliographic Details
Main Authors: Weili Li, Xiaoping Wang, Tianhua Liu, Qian Zhang, Jing Cao, Yanyan Jiang, Qianbin Sun, Chun Li, Wei Wang, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
p53
parkin
mitophagy
mitochondria
doxorubicin
cardiotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.813370/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.813370/full

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