β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis

β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis

Background: Inflammation-related NLRP3/Caspase-1/GSDMD-mediated pyroptosis is involved in the progression of ulcerative colitis (UC). β-sitosterol (SIT) was reported to have anti-inflammatory effects on experimental colitis, while the regulation of SIT on pyroptosis is unclear. Therefore, the presen...

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Bibliographic Details
Main Authors: Di Zhang, Fei Ge, Jing Ji, Yu-Jing Li, Fu-Rong Zhang, Shu-Yan Wang, Shu-Jing Zhang, Dong-Mei Zhang, Meng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
β-sitosterol
ulcerative colitis
inflammatory factors
Caspase-1
GSDMD
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1218477/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1218477/full

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